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Serologic surveys indicate that the acquired form of toxoplasmosis in adults is widespread and frequent (about 40 percent of American city dwellers have speci c antibodies); however, cases of clinically evident active infection are rare It is of interest that in 1975 the medical literature contained only 45 well-documented cases of acquired adult toxoplasmosis (Townsend et al); moreover, in half of them there was an underlying systemic disease (malignant neoplasms, renal transplants, collagen vascular disease) that had been treated intensively with immunosuppressive agents Now, innumerable cases of acquired toxoplasmosis are being seen because it is the most common cause of focal cerebral lesions in patients with AIDS (see Chap 33, page 646) Frequently, the symptoms and signs of infection with Toxoplasma are assigned to the primary disease with which toxoplasmosis is associated, and an opportunity for effective therapy is missed The clinical picture in patients without AIDS varies There may be a fulminant, widely disseminated infection with a rickettsia-like rash, encephalitis, myocarditis, and polymyositis Or the neurologic signs may consist only of myoclonus and asterixis, suggesting a metabolic encephalopathy More often, there are signs of a meningoencephalitis, ie, seizures, mental confusion, meningeal irritation, coma, and a lymphocytic pleocytosis and increased CSF protein The brain in such cases shows foci of in ammatory necrosis (Fig 32-7), with free and encysted T gondii organisms scattered throughout the white and gray matter Rarely, large areas of necrosis manifest themselves as one or more mass lesions Or, a nodular lesion is detected on MR or CT imaging that is performed for other reasons

ption prices are developed based on the same system as their underlying asset counterparts The prices are actual trades between two parties to establish the quote you see on your computer screen Determining the price at which an option should be bid or offered is a process of calculating the value of the option in relationship to the underlying asset Several option models have been developed over the years to establish the theoretical value of options in relation to the trade of the underlying and are a continuous source of academic debate regarding the pros and cons of each system We won t get into a mathematical discussion of each system, but being familiar with the systems and potential market participants that may be following each system is important to your trading success There is a wealth of information on how option pricing models function and how the data is developed, but as an investor or portfolio manager your purpose is to put the information to work for you In the age of trading software, we have easy access to the academic effort on option pricing We want to focus on what do with the information to develop successful trading strategies

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