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Figure 34-2 Arrangement of the major arteries on the right side carrying blood from the heart to the brain Also shown are collateral vessels that may modify the effects of cerebral ischemia For example, the posterior communicating artery connects the internal carotid and the posterior cerebral arteries and may provide anastomosis between the carotid and basilar systems Over the convexity, the subarachnoid interarterial anastomoses linking the middle, anterior, and posterior cerebral arteries are shown, with insert A illustrating that these anastomoses are a continuous network of tiny arteries forming a border zone between the major cerebral arterial territories Occasionally a persistent trigeminal artery connects the internal carotid and basilar arteries proximal to the circle of Willis, as shown in insert B Anastomoses between the internal and external carotid arteries via the orbit are illustrated in insert C Wholly extracranial anastomoses from muscular branches of the cervical arteries to vertebral and external carotid arteries are indicated in insert D

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The configuration for the default implementation is: <barcode> < upc-a > <height>{ length:15mm}</height> <module-width>{length:0.33mm}</module-width> ...
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leading invariably to histologic signs of necrosis These changes do not become apparent for several hours Free fatty acids (appearing as phospholipases) are activated and destroy the phospholipids of neuronal membranes Prostaglandins, leukotrienes, and free radicals accumulate, and intracellular proteins and enzymes are denatured Cells then swell, a process called cellular, or cytotoxic, edema (see page 550) Similar abnormalities affect mitochondria, even before other cellular changes are evident

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Implicit in all discussions of ischemic stroke and its treatment is the existence of a penumbra zone that is marginally perfused and contains viable neurons Presumably this zone exists at the margins of an infarction, which at its core has irrevocably damaged tissue that is destined to become necrotic Using various methods, such a penumbra can be demonstrated in association with some infarctions but not all, and the degree of reversible tissue damage is dif cult to determine The neurons in the penumbra are consid-

Basilar A Penetrating branches of middle cerebral A A1 segment, anterior cerebral artery M1 segment, middle cerebral artery Posterior cerebral A (P1 segment) Superior cerebellar A Short circumferential A Paramedian arteries 5th N 6th N 7th N 8th N Anterior inferior cerebellar A D 12th N B C Mid-pontine 2 mm above pontomedullary junction 6 mm below pontomedullary junction 3rd N A 4 mm below upper border of pons

Superior lateral medullary A 9th and 10th N Inferior lateral medullary A Inferior lateral medullary A Middle lateral medullary A Ant spinal A Posterior inferior cerebellar A Vertebral A

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27 Apr 2018 ... UPCMain . java is a command line program that takes in a 12 digit number and checks to see if it is a valid UPC-A barcode. It does this by ...

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Figure 34-3 Diagram of the brainstem showing the principal vessels of the vertebrobasilar system (the circle of Willis and its main branches) The term M1 is used to refer to the initial (stem) segment of the middle cerebral artery; A1 to the initial segment of the anterior cerebral artery proximal to the anterior communicating artery; A2 to the post-communal segment of the anterior cerebral artery; and P1 and P2 to the corresponding pre- and postcommunal segments of the posterior cerebral artery The letters and arrows on the right indicate the levels of the four cross sections following: A Fig 3416; B Fig 34-15; C Fig 34-14; D Fig 34-13 Although vascular syndromes of the pons and medulla have been designated by sharply outlined shaded areas, one must appreciate that since satisfactory clinicopathologic studies are scarce, the diagrams do not always represent established fact The frequency with which infarcts fail to produce a well-recognized syndrome and the special tendency for syndromes to merge with one another must be emphasized

ered to be stunned by moderate ischemia and subject to salvage if blood ow is restored in a certain period of time As with all infarction, the duration of ischemia plays a role Olsen and colleagues have been able to demonstrate hypoperfused penumbral zones but, interestingly, found that regions just adjacent to them are hyperperfused Furthermore, these investigators and others have shown that elevating the systemic blood pressure or improving the rheologic ow properties of blood in small vessels by hemodilution improves ow in the penumbra; however, attempts to use these techniques in clinical work have met with mixed success The phenomenon of cerebrovascular autoregulation is appropriately introduced here Over a range of mean blood pressures of approximately 50 to 150 mm Hg, the small pial vessels are able to dilate and to constrict in order to maintain CBF in a relatively narrow range This accommodation eventually fails at the extremes of blood pressure, after which CBF follows systemic pressure passively, either falling precipitously or rising to levels that damage small vessel walls The conditions in which the limits of autoregulation are exceeded are at the extremes of hypertensive encephalopathy at one end and circulatory failure at the other, both of which are discussed in later sections of the chapter

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