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Herpes zoster ( shingles, zona ) is a common viral infection of the nervous system occurring at an overall rate of 3 to 5 cases per 1000 persons per year, with higher rates in the elderly Shingles is distinctly rare in childhood It is characterized clinically by radicular pain, a vesicular cutaneous eruption, and, less often, by segmental sensory and delayed motor loss The pathologic changes consist of an acute in ammatory reaction in isolated spinal or cranial sensory ganglia and lesser degrees of reaction in the posterior and anterior roots, the posterior gray matter of the spinal cord, and the adjacent leptomeninges The neurologic implications of the segmental distribution of the rash were recognized by Richard Bright as long ago as 1831 In ammatory changes in the corresponding ganglia and related portions of the spinal nerves were rst described by von Barensprung in 1862 and were later studied extensively The concept that varicella and zoster are caused by the same agent was introduced by von Bokay in 1909 and was subsequently established by Weller and his associates (1954, 1958) The common agent, referred to as varicella or varicella zoster virus (VZV), is a DNA virus that is similar in structure to the virus of herpes simplex These and other historical features of herpes zoster have been reviewed by DennyBrown and Adams and by Weller and their colleagues Pathology and Pathogenesis The pathologic changes in VZV infection are unique and consist of one or more of the following: (1) an in ammatory reaction in several unilateral adjacent sensory ganglia of the spinal or cranial nerves, frequently of such intensity as to cause necrosis of all or part of the ganglion, with or without hemorrhage; (2) an in ammatory reaction in the spinal roots and peripheral nerve contiguous with the involved ganglia; (3) a less common poliomyelitis that closely resembles acute anterior poliomyelitis but is readily distinguished by its unilaterality, segmental localization, and greater involvement of the dorsal horn, root, and ganglion; and (4) a relatively mild leptomeningitis, largely limited to the involved spinal or cranial segments and nerve roots These pathologic changes are the substratum of the neuralgic pains, the pleocytosis, and the local palsies that may attend and follow the VZV infection There may also be a delayed cerebral vasculitis (see further on) As to pathogenesis, herpes zoster represents a spontaneous reactivation of VZV infection, which becomes latent in the neurons of sensory ganglia following a primary infection with chickenpox (Hope-Simpson) This hypothesis is consistent with the differences in the clinical manifestations of chickenpox and herpes zoster, even though both are caused by the same virus Chickenpox is highly contagious by respiratory aerosol, has a well-marked seasonal incidence (winter and spring), and tends to occur in epidemics Zoster, on the other hand, is not communicable (except to a person who has not had chickenpox), occurs sporadically throughout the year, and shows no increase in incidence during epidemics of chickenpox In patients with zoster, there is practically always a past history of chickenpox Such a history may be lacking in rare instances of herpes zoster in infants, but in these cases there has usually been prenatal maternal contact with VZV VZV DNA is localized primarily in trigeminal and thoracic ganglion cells, corresponding to the dermatomes in which chickenpox lesions are maximal and that are most commonly involved by VZV (Mahalingam et al) The supposition is that in both zoster and varicella infections the virus makes its way from the cutaneous. convert html to pdf itextsharp vb.net . NET PDF SDKs - Foxit Developers | PDF SDK technology
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