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Fibrosis, or formation of collagenous tissue, was perhaps one of the earliest recognized forms of occupational diseases. Silicosis, resulting from inhalation of silica (SiO2 ), is thought to involve rst the uptake of the particles by macrophages and lysosomal incorporation, followed by rupture of the lysosomal membrane and release of lysosomal enzymes into the cytoplasm of the macrophages. Thus the macrophage is digested by its own enzymes. After lysis, the free silica is released to be ingested by fresh macrophages, and the cycle continues. It is also thought that the damaged macrophages release chemicals that are instrumental in initiating the collagen formation in the lung. Fibrosis may become massive and impair the respiratory function of the lung signi cantly. Asbestosis was recognized as long ago as 1907; however, the magnitude of the risk has become apparent only recently, primarily due to the increased incidence of lung cancer among asbestosis sufferers, especially those who are also cigarette smokers. Both silicosis and asbestosis are thought to be premalignant conditions.

Accordingly, traf c can be seen as the superposition of user activities that arrive according to a Poisson process but carry an amount of work that is drawn from a heavy-tailed distribution The authors nd that for wide-area traf c the arrival process of sessions is consistent with Poisson processes and that their durations are heavy tailed Park et al [36] and Crovella and Bestavros [8] showed a possible causal relationship between heavytailed transfer durations and le sizes on UNIX le systems 1522 Self-Similarity of Connection Arrival Processes.

a The average number of plaques for n 3 independent experiments from the 10 3 TMEV dilution are shown in Figure 13.5. b p < 0.0001 for all BTCmPEG concentrations. p < 0.0001 for the 5 20 kDa combination relative to the 5 kDa polymer at all concentrations and for the 20 kDa polymer at derivatization concentration <10 mM.

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To be able to study the arrival process of sessions, Paxson and Floyd equate sessions with TCP connections of applications such as TELNET and FTP connections, which, at the time of the study (1995), were among the most popular applications on the

Emphysema is characterized by an enlargement of the airspaces with the destruction of the gas-exchange surface area. The loss of tissue and air-trapping capacity results in a distended lung that no longer effectively exchanges O2 and CO2 . Although cigarette smoking is the major cause of emphysema, other toxicants can also cause this condition.

Internet They point out that other arrival processes including FTP DATA connection arrivals and SMTP connection arrivals are not consistent with Poisson processes A Poisson process arises when users initiate actions more or less independently While this may have been the case for FTP and TELNET sessions in 1995, the Internet has changed since then It has grown beyond expectation so that an enormous amount of information is available, and its dominant application is the World Wide Web (or the Web) The Web contributes more than half of the packets and more than two-thirds of all TCP connections to the traf c of commercial ISPs such as AT&T's WorldNet During a Web user session, a user is likely to download not just one single Web object, since most Web pages consist of 3 to 4 embedded images [4, 18], but also different Web pages.

FIGURE 16.6 Modi cation of the CMV host MRC-5 cells with BTCmPEG (5 kDa) prevents viral fusion and entry. Viral infection was determined by immunostaining for IE72. As shown, an mPEG dose-dependent antiviral response is noted. Both the initial cell entry and secondary entry by progeny virus are blocked by the grafted mPEG as noted by the 24, 48, and 72 hour timepoints. Shown are the mean SD of a minimum of three independent experiments. **p < 0.001; *p < 0.05 from positive control.

Numerous agents, including microorganisms, spores, dust, and chemicals, are known to elicit allergic responses resulting in constriction of the airways. Several diverse examples are farmer s lung from the spores of a mold that grows on damp hay, maple bark stripper s disease from spores of a fungus growing on maple trees, cheese washer s lung from penicillin spores, and mushroom picker s lung from the mushroom spores. Byssinosis comes from the inhalation of cotton, ax, or hemp dusts. This condition, however, does not seem to result from bacterial or fungal exposure but from an apparent toxicant or allergen associated with the plant dusts.

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